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24-06-2009 - Secondary immune-mediated thrombocytopenia in dogs naturally infected by Leishmania infantum

Secondary immune-mediated thrombocytopenia in dogs naturally infected by Leishmania infantum

L. Cortese, DVM, PhD1, M. Sica, Biol, PhD3, D. Piantedosi, DVM, PhD1, G. Ruggiero, MD, PhD3, M. E. Pero, DVM, PhD2, G. Terrazzano, ChmD, PhD4, V. Mastellone, DM, PhD5 and P. Ciaramella, DVM1

1 Department of Veterinary Clinical Sciences, Internal Medicine Section, Functions and Technologies, University of Naples Federico II, Via Delpino 1, 80137 Naples, Italy
2 Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Via Delpino 1, 80137 Naples, Italy
3 Department of Cellular and Molecular Biology and Pathology, University Naples Federico II, via Pansini 5, 80131, Napoli, Italy
4 Faculty of Science, University of Basilicata, Via N Sauro, 85, 85100 Potenza, Italy
5 Department of Experimental and Clinical Medicine, University of Magna Grecia, Viale Europa (Germaneto), 88100 Catanzaro, Italy

Correspondence: E-mail for correspondence: lcortese@unina.it

Forty-four dogs naturally infected by Leishmania infantum were divided into two groups: 20 thrombocytopenic dogs with fewer than 150 x 109 platelets/l, and 24 non-thrombocytopenic dogs with more than 200 x 109 platelets/l. Ten clinically healthy dogs were used as controls. A haematological profile was obtained and the dogs' serum was used to assess the presence of platelet-binding IgM and IgG antibodies using a flow cytometry technique. Nineteen of the 20 thrombocytopenic dogs, and 13 of the 24 non-thrombocytopenic dogs had detectable levels of platelet-binding immunoglobulins, but none of the control dogs did so. The differences were significantly different for both IgM and IgG platelet-binding antibodies.


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